Changsha Central Hospital (CCH) received equipment under the ORET-programme of the Dutch government in 2004. To bring quality of care to a next level, a technical assistance and training programme was implemented by MeduProf-S, covering areas such as hospital management and clinical skills. AMPC was subcontracted by MeduProf-S to implement a hospital hygiene and waste management capacity building programme. Firstly, AMPC assessed the existing situation of CCH’s hospital hygiene and waste management in terms of policies, protocols, responsibilities, available equipment and current practices of staff. The outcomes were compared to national and international standards and best practices to identify strengths and weaknesses and to provide specific recommendations for improvement. Based on the outcomes and together with the main stakeholders, a tailormade training programme was designed and implemented by AMPC. This was based on a Train-the-Trainers approach to maximise the impact of the programme and to guarantee sustainability of the transfer of knowledge and skills.